<div dir="ltr">Hi James,<div><br></div><div>Eric Forgoston was kind enough to gp through the paper and made edits - I resolved most issues and only a few comments are left for experts on annotation and to resolve some differences between John Rice and Alex. </div><div><br></div><div>I ask that we avoid endless edits and start the approval process for submission. We should not drag editing anymore - Eric's last edits were at the level of punctuation and proofs so we should be good. And this is after many edits and checks I made myself and I know Hana and Alex also made edits. </div><div><br></div><div>Unless someone shouts, I will start the approval process tomorrow - so I ask contributors to give the papr a last peek before you are asked to say Yes/NO towards submission with your name on it. </div><div><br></div><div>Hopefully this last warning is sufficient and you will all find the paper in good shape. </div><div><br></div><div>               Jacob</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Thu, Oct 28, 2021 at 9:26 PM Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com">jacob.barhak@gmail.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr">Hi James,<div><br></div><div>Apologies - I must have missed your email request. If anyone else wants access and did not get it, please let me know - I will do my best to give you access within a day. </div><div><br></div><div>For those who have access. Please no more additions - from now on just corrections of typos, grammer, and grave errors. Anything else, please leave a comment and we can discuss it.</div><div><br></div><div>I really want the paper out quickly - hopefully we can finish this and submit quickly.</div><div><br></div><div>               Jacob</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Thu, Oct 28, 2021 at 3:17 PM James A Glazier <<a href="mailto:jaglazier@gmail.com" target="_blank">jaglazier@gmail.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
  
    
  
  <div>
    <p>Dear Jacob:</p>
    <p>I would like to review the document. I had asked for access a few
      weeks ago. Happy to look in the next few days.</p>
    <p>JAG<br>
    </p>
    <div>On 10/24/2021 4:40 AM, Jacob Barhak
      wrote:<br>
    </div>
    <blockquote type="cite">
      
      <div dir="ltr">Hi Eric, 
        <div><br>
        </div>
        <div>You are the last one I remember who wanted to edit. Please
          check the manuscript</div>
        <div><a href="https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit?usp=sharing" target="_blank">https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit?usp=sharing</a><br>
        </div>
        <div><br>
        </div>
        <div>I finished editing the references and am almost ready for
          transformation to match the guidelines.  I finished addressing
          the editor requesting for removal of bullet points everywhere
          but the stochastic section . </div>
        <div><br>
        </div>
        <div>I ask that you do not add any more references and focus
          only on text in the stochastic section. Handling the
          references took about 4 hours alone and still needs
          inspection. </div>
        <div><br>
        </div>
        <div>However, I will appreciate help with minor proofs - I made
          significant changes so there is a chance for typos still. 
          Some of the changes have been made after more than 12 hours of
          consecutive work. So polish will help - yet no more major
          changes. </div>
        <div><br>
        </div>
        <div>The tasks left to do are:</div>
        <div>- Ask John Gennari to inspect the paper again - it has
          major contributions from his version and he should join the
          authors list - I must be ask again </div>
        <div>- Finish the edits to the stochastic section - Eric - you
          asked for this</div>
        <div>- Finish formatting to fit the Journal guidelines </div>
        <div>- Add a cover letter and split the paper into sections to
          be uploaded to the journal web site</div>
        <div>- Approve the version with all authors - we must do this
          again and get full approval - this may take a while</div>
        <div>- Determine who else wants to be listed as
          corresponding author - currently I marked Marcell and myself,
          yet others may want to correspond.  </div>
        <div>- Upload the paper to the journal submission system</div>
        <div><br>
        </div>
        <div>I hope for no obstacles and full cooperation to make the
          process smooth.</div>
        <div><br>
        </div>
        <div>                     Jacob</div>
        <div><br>
        </div>
        <div><br>
        </div>
      </div>
      <br>
      <div class="gmail_quote">
        <div dir="ltr" class="gmail_attr">On Sat, Oct 23, 2021 at 9:08
          PM Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com" target="_blank">jacob.barhak@gmail.com</a>>
          wrote:<br>
        </div>
        <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
          <div dir="ltr">So Gilberto,
            <div><br>
            </div>
            <div>The last approved version is the only one we can
              continue from - this is unfortunate that there is a need
              to back port some modifications - hence the conversation
              with Eric and Hana - yet to maintain traceability and
              honor all contributors - this is necessary.</div>
            <div><br>
            </div>
            <div>And yes, there will be some differences - it's
              unavoidable. Yet I pretty much merged the other traceable
              versions by now. If I missed anything - I apologize -
              there is a limit to human capabilities. </div>
            <div><br>
            </div>
            <div>We discussed this multiple times on this list, if this
              is a stopper for you, let me know immediately so I will
              stop work to resolve this issue.</div>
            <div><br>
            </div>
            <div>Otherwise, I will continue - I think I resolved most
              points except from references and removal of bullets -
              still working on that and I will have to deal with
              modifying conclusions at the end. </div>
            <div><br>
            </div>
            <div>And Gilberto, if you want to contribute time towards
              changing order of sections and handle references to comply
              with the target journal guidelines, please go online on
              the Jitsi channel.and I will show you the extent of work
              needed. I will be here for at least 3 more hours - until
              midnight - yet to be efficient, please join on jitsi if
              you want to talk while I continue modifications. </div>
            <div><br>
            </div>
            <div>I hope I can finish most of the work except references
              perhaps by midnight. </div>
            <div><br>
            </div>
            <div>               Jacob</div>
            <div><br>
            </div>
            <div><br>
            </div>
          </div>
          <br>
          <div class="gmail_quote">
            <div dir="ltr" class="gmail_attr">On Sat, Oct 23, 2021 at
              8:32 PM Gilberto Gonzalez-Parra <<a href="mailto:gilberto.gonzalezparra@nmt.edu" target="_blank">gilberto.gonzalezparra@nmt.edu</a>>
              wrote:<br>
            </div>
            <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
              <div dir="ltr">Hi Jacob,
                <div><br>
                </div>
                <div>I noticed that we are not using the last version
                  that has many modifications. Are you using the
                  previous version that was originally submitted to
                  cureus ? and trying to incorporate the changes of the
                  last version ?</div>
                <div><br>
                </div>
                <div>I noticed that the section/challenge <span style="font-size:11pt;line-height:107%;font-family:Arial,sans-serif;color:black"><b>Barriers
                      to model implementation and real-world use</b> was
                    removed. I think in one of the emails it says that
                    there is no solution proposed for this. I can write
                    some general ideas for this. </span></div>
                <div><span style="font-size:11pt;line-height:107%;font-family:Arial,sans-serif;color:black"><br>
                  </span></div>
                <div><span style="font-size:11pt;line-height:107%;font-family:Arial,sans-serif;color:black">In
                    the current version in the table it appears "</span><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap"><b>Model application and implementation barriers</b>" just after "</span><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;font-weight:700;white-space:pre-wrap">Missing Annotations in Models" </span><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap"> but later in the document appears just before stochastic modeling. I think we should keep the same order that is in the table. The article would look better organized.</span></div>
                <div><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap">
</span></div>
                <div><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap">Best,</span></div>
                <div><br>
                </div>
                <div>
                  <div>
                    <div dir="ltr">
                      <div dir="ltr">
                        <div>
                          <div dir="ltr">
                            <div>
                              <div dir="ltr">
                                <div>
                                  <div dir="ltr">***************************************************************************</div>
                                  <div dir="ltr">Gilberto C.
                                    Gonzalez-Parra, <span>Ph.D
                                      in Applied Mathematics.</span></div>
                                  <div dir="ltr"><font face="Helvetica
                                      Neue, Helvetica, Arial, Lucida
                                      Grande, sans-serif, serif,
                                      EmojiFont" color="#000000"><span style="font-size:13px">Faculty
                                        of the </span></font>Mathematics
                                    Department
                                    <div>
                                      <div>New Mexico Tech, NM, USA.</div>
                                    </div>
                                    <div>****************************************************************************</div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                  <br>
                </div>
              </div>
              <br>
              <div class="gmail_quote">
                <div dir="ltr" class="gmail_attr">On Sat, Oct 23, 2021
                  at 5:38 PM Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com" target="_blank">jacob.barhak@gmail.com</a>>
                  wrote:<br>
                </div>
                <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                  <div dir="ltr">Hi Eric, and also greeting for the
                    other paper contributors 
                    <div>
                      <div><br>
                      </div>
                      <div>Here is a real time update just to give an
                        idea of current editing status.</div>
                      <div><br>
                      </div>
                      <div>It took almost 6 hours to get the
                        manuscript to the point that contributions from
                        Sheriff, Alex, John Gennari, and Hana were
                        integrated. I assume Eric will add his edits
                        later - since those are in one section, it
                        should not cause any conflict. However, Eric,
                        please be careful when editing the
                        stochastic section. Pease look at the comments
                        Hana and I exchanged. I am also adding the chat
                        between us so it will be easier on you:</div>
                      <div><br>
                      </div>
                      <div>"</div>
                      <div>Hi Hana<br>
                        Can you see the chat?<br>
                        I can. There's just a lot going on around here
                        right now, so I'm not fast with typing<br>
                        I put the references in the comments, can you
                        see them?<br>
                        Yes I See them - yet you will have to ensure
                        that this is your text - you see, you copied
                        text from a document where we do not have
                        contributor history - this was the main issue -
                        so you will have not to prove this was your text
                        and only your text -  this is the problem I am
                        faced with - I have to establish tracability -
                        in this document I know you added the text - yet
                        I cannot verify that you did not include text
                        from anonymous since I already concluded you
                        added text from Alex - this is how I stumbled on
                        this - I apologize yet I really am serious about
                        tracing back authorship..<br>
                        And thanks fro helping<br>
                        If you want, you can join jitsi: <a href="https://meet.jit.si/CollaborativePaperEditing" target="_blank">https://meet.jit.si/CollaborativePaperEditing</a>
                          and we can chat using voice<br>
                        I just saw your comment - it is public
                        confirmation - this is good enough  thank you <br>
                        The first two paragraphs are from the original
                        paper. The third paragraph is from Alex. The
                        last two are mine. It looks like someone (other
                        than me) italicized the in vitro and in vivo and
                        changed the verb on the "Even data that are..."
                        (I had is), but everything else is mine.<br>
                        If you can modify things to the original version
                        you added - it will be better - if someone
                        manipulated the text I want to remove it - even
                        if it is small changes <br>
                        I know you're trying to get things done today,
                        but I'll be out tonight, so if anything else
                        comes up, I probably won't get to it until the
                        morning. <br>
                        Well, "are" is the correct verb there, so that
                        should probably stay. I can remove the
                        italicization.<br>
                        Do not worry - I am making good progress and may
                        not need help until I am done - I appreciate the
                        help and the fact you are working on it over the
                        weekend -  I will later also make this chat
                        public for transparency.  I do believe you have
                        contributed a lot to this paper - its not the
                        first time you are going over it - I can only
                        thank you . <br>
                        the are was my change today I believe so its not
                        a problem - yet google suggests is instead I
                        guess is and are both acceptable with data ....
                        nevermind that.<br>
                        "</div>
                      <div><br>
                      </div>
                      <div>I did my best to keep all ideas and other
                        texts intact and there are many comments to mark
                        changes  - the paper became longer, yet not too
                        much and I feel it is still reasonable .</div>
                      <div><br>
                      </div>
                      <div>I am now moving to the next part of complying
                        with the requests of the editor:</div>
                      <div>1) Determine authorship</div>
                      <div>2) Converging format to journal guidelines -
                        this also means references</div>
                      <div>3) Detach from group - some elements already
                        marked</div>
                      <div>4) Revise bullet points into paragraphs</div>
                      <div><br>
                      </div>
                      <div>I plan to continue editing until midnight CST
                        with a break for dinner - so if anyone has
                        comments - please feel free to join the open
                        channel that shows the editing and influence
                        real-time.</div>
                      <div><br>
                      </div>
                      <div>Hopefully you will find the merged version in
                        order. </div>
                      <div><br>
                      </div>
                      <div>               Jacob</div>
                      <div><br>
                      </div>
                      <div><br>
                      </div>
                      <div><br>
                      </div>
                      <div><br>
                      </div>
                      <div><br>
                      </div>
                    </div>
                  </div>
                  <br>
                  <div class="gmail_quote">
                    <div dir="ltr" class="gmail_attr">On Sat, Oct 23,
                      2021 at 2:50 PM Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com" target="_blank">jacob.barhak@gmail.com</a>>
                      wrote:<br>
                    </div>
                    <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                      <div dir="ltr">Hi Eric,
                        <div><br>
                        </div>
                        <div>You wanted to edit the stochastic section -
                          you are welcome to do it. Yet I ask no more
                          references or deletions - I am overloaded
                          already. </div>
                        <div><br>
                        </div>
                        <div>The version benign edited is:</div>
                        <div><a href="https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit" target="_blank">https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit</a><br>
                        </div>
                        <div><br>
                        </div>
                        <div>You will need to login so that your edits
                          will be traceable.</div>
                        <div><br>
                        </div>
                        <div>You can join me while editing in:</div>
                        <div><a href="https://meet.jit.si/CollaborativePaperEditing" target="_blank">https://meet.jit.si/CollaborativePaperEditing</a><br>
                        </div>
                        <div><br>
                        </div>
                        <div>I am sharing my screen there while
                          editing. </div>
                        <div><br>
                        </div>
                        <div>You might be able to help me with other
                          sections as well.</div>
                        <div><br>
                        </div>
                        <div>              Jacob</div>
                        <div><br>
                        </div>
                      </div>
                      <br>
                      <div class="gmail_quote">
                        <div dir="ltr" class="gmail_attr">On Sat, Oct
                          23, 2021 at 2:44 PM Eric Forgoston <<a href="mailto:eric.forgoston@montclair.edu" target="_blank">eric.forgoston@montclair.edu</a>>
                          wrote:<br>
                        </div>
                        <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                          <div dir="ltr">Hi Jacob,
                            <div><br>
                            </div>
                            <div>If you give me a link to the paper you
                              are editing and edit access to the paper I
                              can update the stochastic section.</div>
                            <div><br>
                            </div>
                            <div>Cheers,</div>
                            <div><br>
                            </div>
                            <div>Eric<br clear="all">
                              <div>
                                <div dir="ltr">
                                  <div dir="ltr">
                                    <div>
                                      <div dir="ltr">
                                        <div>
                                          <div dir="ltr">
                                            <div>
                                              <div dir="ltr">
                                                <div>
                                                  <div dir="ltr">
                                                    <div>
                                                      <div dir="ltr">
                                                        <div>
                                                          <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div><span>---------------------<br>
                                                          Dr. Eric
                                                          Forgoston<br>
                                                          Professor of
                                                          Applied
                                                          Mathematics<br>
                                                          Chair,
                                                          Department of
                                                          </span><span><span><span>Applied
                                                          Mathematics
                                                          and Statistics</span></span><br>
                                                          Montclair
                                                          State
                                                          University<br>
                                                          Montclair, NJ 
                                                          07043 USA<br>
                                                          +1 973
                                                          655-7242 <br>
                                                          <span><a href="https://eric-forgoston.github.io/" target="_blank">https://eric-forgoston.github.io/</a></span></span><br>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                        </div>
                                                      </div>
                                                    </div>
                                                  </div>
                                                </div>
                                              </div>
                                            </div>
                                          </div>
                                        </div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                              <br>
                            </div>
                          </div>
                          <br>
                          <div class="gmail_quote">
                            <div dir="ltr" class="gmail_attr">On Sat,
                              Oct 23, 2021 at 1:39 PM Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com" target="_blank">jacob.barhak@gmail.com</a>>
                              wrote:<br>
                            </div>
                            <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                              <div dir="ltr">Greetings Paper
                                Contributors,
                                <div><br>
                                </div>
                                <div>The paper editing process started
                                  and you can follow it live on:</div>
                                <div><a href="https://meet.jit.si/CollaborativePaperEditing" target="_blank">https://meet.jit.si/CollaborativePaperEditing</a><br>
                                </div>
                                <div><br>
                                </div>
                                <div>I will keep the channel open as
                                  long as I am editing so that the
                                  process will be as transparent as
                                  possible. </div>
                                <div><br>
                                </div>
                                <div>The first step would be to
                                  reconcile the differences between
                                  those 4 versions traceable back to
                                  authors:</div>
                                <div><a href="https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit" target="_blank">https://docs.google.com/document/d/1IMEgmdNkx-EsnOjGuegpenSIMmKIkK00Lc8Gred3QxM/edit</a> 
                                  - the submitted version<br>
                                </div>
                                <div><a href="https://docs.google.com/document/d/1VvyP3YZQdQYjj8DFKOpQ4pn_0pdDGgiT/edit" target="_blank">https://docs.google.com/document/d/1VvyP3YZQdQYjj8DFKOpQ4pn_0pdDGgiT/edit</a> 
                                  - first committed version<br>
                                </div>
                                <div><a href="https://docs.google.com/document/d/1Ag4ipuybjtthxgV0YjXqYP7AwwNSYcWh/edit" target="_blank">https://docs.google.com/document/d/1Ag4ipuybjtthxgV0YjXqYP7AwwNSYcWh/edit</a> 
                                  - first committed version<br>
                                </div>
                                <div><a href="https://drive.google.com/file/d/1U_lTHrV6STXWNT3GiCepvsLk1WdYgzN5/view" target="_blank">https://drive.google.com/file/d/1U_lTHrV6STXWNT3GiCepvsLk1WdYgzN5/view</a>
                                  - its the first document posted<br>
                                </div>
                                <div><br>
                                </div>
                                <div>After this step is done I will move
                                  towards adhering to those
                                  instructions:</div>
                                <div><a href="https://www.frontiersin.org/about/author-guidelines" target="_blank">https://www.frontiersin.org/about/author-guidelines</a><br>
                                </div>
                                <div><br>
                                </div>
                                <div>I estimate I will be working till
                                  late today with very few breaks and
                                  hopefully make sufficient progress.</div>
                                <div><br>
                                </div>
                                <div>Feel free to visit and perhaps even
                                  help. If you do, please raise your
                                  voice so I can hear you - I am sharing
                                  my screen and not seeing the video
                                  when I edit - so you will have to let
                                  me know you are in the room. </div>
                                <div><br>
                                </div>
                                <div>Hopefully some of you will visit.</div>
                                <div><br>
                                </div>
                                <div>              Jacob</div>
                              </div>
                              <br>
                              <div class="gmail_quote">
                                <div dir="ltr" class="gmail_attr">On
                                  Fri, Oct 22, 2021 at 2:52 PM Jacob
                                  Barhak <<a href="mailto:jacob.barhak@gmail.com" target="_blank">jacob.barhak@gmail.com</a>>
                                  wrote:<br>
                                </div>
                                <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                  <div dir="auto">Thanks Sheriff,  
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">With your green
                                      light I can start editing</div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">Eric,  the base of
                                      John's version will be merged to
                                      the best of my ability, yet
                                      unfortunately, it has omissions
                                      and later version based on it are
                                      not traceable back to
                                      contributors,  so I can only use
                                      some of  the base. </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">If you want to
                                      repeat edits so those will be
                                      traceable it is possible. Yet we
                                      cannot copy verbatim without going
                                      to details. </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">To make things
                                      easier,  I will open a channel
                                      over the weekend during edits
                                      where anyone can join and
                                      communicate while watching the
                                      edits live.  </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">Hopefully it will
                                      make things smoother. </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto">            Jacob</div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto"><br>
                                    </div>
                                    <div dir="auto"><br>
                                    </div>
                                  </div>
                                  <br>
                                  <div class="gmail_quote">
                                    <div dir="ltr" class="gmail_attr">On
                                      Fri, Oct 22, 2021, 13:40 Eric
                                      Forgoston <<a href="mailto:eric.forgoston@montclair.edu" target="_blank">eric.forgoston@montclair.edu</a>>
                                      wrote:<br>
                                    </div>
                                    <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                      <div dir="ltr">
                                        <div dir="ltr">Dear Jacob and
                                          all,
                                          <div><br>
                                          </div>
                                          <div>I suggest, as others have
                                            done, to use the John G.
                                            version as structurally it
                                            has already cleaned up most
                                            of the issues raised by the
                                            Editor, and also has many
                                            revised and improved
                                            sections. In particular, the
                                            stochastic section that I
                                            worked on with others is far
                                            superior to the one in the
                                            paper submitted to
                                            Frontiers.</div>
                                          <div><br>
                                          </div>
                                          <div>Best wishes,</div>
                                          <div><br>
                                          </div>
                                          <div>Eric<br clear="all">
                                            <div>
                                              <div dir="ltr">
                                                <div dir="ltr">
                                                  <div>
                                                    <div dir="ltr">
                                                      <div>
                                                        <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div>
                                                          <div dir="ltr">
                                                          <div><span>---------------------<br>
                                                          Dr. Eric
                                                          Forgoston<br>
                                                          Professor of
                                                          Applied
                                                          Mathematics<br>
                                                          Chair,
                                                          Department of
                                                          </span><span><span><span>Applied
                                                          Mathematics
                                                          and Statistics</span></span><br>
                                                          Montclair
                                                          State
                                                          University<br>
                                                          Montclair, NJ 
                                                          07043 USA<br>
                                                          +1 973
                                                          655-7242 <br>
                                                          <span><a href="https://eric-forgoston.github.io/" rel="noreferrer" target="_blank">https://eric-forgoston.github.io/</a></span></span><br>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
                                                        </div>
                                                      </div>
                                                    </div>
                                                  </div>
                                                </div>
                                              </div>
                                            </div>
                                            <br>
                                          </div>
                                        </div>
                                        <br>
                                        <div class="gmail_quote">
                                          <div dir="ltr" class="gmail_attr">On Fri,
                                            Oct 22, 2021 at 12:57 PM
                                            Rahuman Sheriff <<a href="mailto:sheriff@ebi.ac.uk" rel="noreferrer" target="_blank">sheriff@ebi.ac.uk</a>>
                                            wrote:<br>
                                          </div>
                                          <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                            <div>Congratulations
                                              Marcella,
                                              <div><br>
                                              </div>
                                              <div>Hi Jacob and all,</div>
                                              <div><br>
                                              </div>
                                              <div>As Tomas mentioned,
                                                John G’s version is bit
                                                more organised.  </div>
                                              <div>Although it would be
                                                nice to take that one
                                                forward, I also fine
                                                with you recovering your
                                                version incorporating
                                                requested changes
                                                including mine. </div>
                                              <div>I would prefer this
                                                manuscript progresses
                                                ahead, instead of
                                                another long discussion.
                                                 </div>
                                              <div>Green signal from my
                                                side.</div>
                                              <div>Best regards</div>
                                              <div>Sheriff</div>
                                              <div><br>
                                              </div>
                                              <div>
                                                <div>
                                                  <div><br>
                                                    <blockquote type="cite">
                                                      <div>On 22 Oct
                                                        2021, at 01:49,
                                                        Jacob Barhak
                                                        <<a href="mailto:jacob.barhak@gmail.com" rel="noreferrer" target="_blank">jacob.barhak@gmail.com</a>>
                                                        wrote:</div>
                                                      <br>
                                                      <div>
                                                        <div dir="auto" style="font-family:Helvetica;font-size:12px;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration:none">Congratulations
                                                          Marcella, 
                                                          <div dir="auto"><br>
                                                          </div>
                                                          <div dir="auto">Indeed
                                                          you bring good
                                                          news. <br>
                                                          <div dir="auto"><br>
                                                          </div>
                                                          <div dir="auto">You
                                                          should not
                                                          worry about
                                                          the
                                                          manuscript. 
                                                          You have done
                                                          plenty and we
                                                          can handle if
                                                          from now on, 
                                                          you can focus
                                                          on your
                                                          family. </div>
                                                          <div dir="auto"><br>
                                                          </div>
                                                          <div dir="auto">   
                                                               Jacob</div>
                                                          </div>
                                                        </div>
                                                        <br style="font-family:Helvetica;font-size:12px;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration:none">
                                                        <div class="gmail_quote" style="font-family:Helvetica;font-size:12px;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration:none">
                                                          <div dir="ltr" class="gmail_attr">On Thu, Oct 21, 2021, 10:33 Torres, Marcella <<a href="mailto:mtorres@richmond.edu" rel="noreferrer" target="_blank">mtorres@richmond.edu</a>>
                                                          wrote:<br>
                                                          </div>
                                                          <blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                                          <div>
                                                          <div dir="auto" style="direction:ltr;margin:0px;padding:0px;font-family:sans-serif;font-size:11pt">This
                                                          streamlined
                                                          approach
                                                          sounds good to
                                                          me; thanks
                                                          Jacob for
                                                          offering to
                                                          coordinate
                                                          edits. I think
                                                          the one month
                                                          deadline is a
                                                          good maximum,
                                                          since
                                                          Frontiers
                                                          favors quick
                                                          turnaround.<span id="gmail-m_-283976446094332176gmail-m_-6812091254919142191gmail-m_-2697268861042949202gmail-m_-1689782665546364892gmail-m_454394027104465375gmail-m_1100449795159862914gmail-m_-3690383742767868331gmail-m_208464925022974690gmail-m_-6684231236743761144gmail-m_5330779350599904174m_6811753030514762076gmail-m_-4652177745642668797m_-8816081919050643472ms-outlook-android-cursor"></span><br>
                                                          <br>
                                                          </div>
                                                          <div dir="auto" style="direction:ltr;margin:0px;padding:0px;font-family:sans-serif;font-size:11pt">I
                                                          don't insist
                                                          on
                                                          participating
                                                          in the
                                                          revisions, but
                                                          I am available
                                                          to help with
                                                          cleaning up
                                                          grammar,
                                                          typos, and so
                                                          on - I noticed
                                                          quite a few
                                                          minor issues
                                                          when reviewing
                                                          the document
                                                          for
                                                          submission.
                                                          However, my
                                                          son was born a
                                                          few days ago
                                                          and I have
                                                          limited time.<span> </span><br>
                                                          <br>
                                                          </div>
                                                          <div dir="auto" style="direction:ltr;margin:0px;padding:0px;font-family:sans-serif;font-size:11pt">Marcella</div>
                                                          <hr style="display:inline-block;width:545.578px">
                                                          <div id="gmail-m_-283976446094332176gmail-m_-6812091254919142191gmail-m_-2697268861042949202gmail-m_-1689782665546364892gmail-m_454394027104465375gmail-m_1100449795159862914gmail-m_-3690383742767868331gmail-m_208464925022974690gmail-m_-6684231236743761144gmail-m_5330779350599904174m_6811753030514762076gmail-m_-4652177745642668797m_-8816081919050643472divRplyFwdMsg" dir="ltr"><font style="font-size:11pt" face="Calibri, sans-serif"><b>From:</b><span> </span>Jacob
                                                          Barhak <<a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a>><br>
                                                          <b>Sent:</b><span> </span>Wednesday,
                                                          October 20,
                                                          2021 11:53:58
                                                          PM<br>
                                                          <b>To:</b><span> </span>Alexander
                                                          Kulesza <<a href="mailto:alexander.kulesza@novadiscovery.com" rel="noreferrer
                                                          noreferrer" target="_blank">alexander.kulesza@novadiscovery.com</a>><br>
                                                          <b>Cc:</b><span> </span>Hana
                                                          <<a href="mailto:h.dobrovolny@tcu.edu" rel="noreferrer noreferrer" target="_blank">h.dobrovolny@tcu.edu</a>>;
                                                          James Osborne
                                                          <<a href="mailto:jmosborne@unimelb.edu.au" rel="noreferrer noreferrer" target="_blank">jmosborne@unimelb.edu.au</a>>;
                                                          John Rice <<a href="mailto:john.rice@noboxes.org" rel="noreferrer noreferrer" target="_blank">john.rice@noboxes.org</a>>; Torres, Marcella
                                                          <<a href="mailto:mtorres@richmond.edu" rel="noreferrer noreferrer" target="_blank">mtorres@richmond.edu</a>>;<span> </span><a href="mailto:vp-reproduce-subgroup@lists.simtk.org" rel="noreferrer
                                                          noreferrer" target="_blank">vp-reproduce-subgroup@lists.simtk.org</a><span> </span><<a href="mailto:vp-reproduce-subgroup@lists.simtk.org" rel="noreferrer
                                                          noreferrer" target="_blank">vp-reproduce-subgroup@lists.simtk.org</a>>;<span> </span><a href="mailto:vp-integration-subgroup@lists.simtk.org" rel="noreferrer
                                                          noreferrer" target="_blank">vp-integration-subgroup@lists.simtk.org</a><span> </span><<a href="mailto:vp-integration-subgroup@lists.simtk.org" rel="noreferrer
                                                          noreferrer" target="_blank">vp-integration-subgroup@lists.simtk.org</a>>;
                                                          Jonathan Karr
                                                          <<a href="mailto:jonrkarr@gmail.com" rel="noreferrer noreferrer" target="_blank">jonrkarr@gmail.com</a>>;
                                                          John Gennari
                                                          <<a href="mailto:gennari@uw.edu" rel="noreferrer noreferrer" target="_blank">gennari@uw.edu</a>>;
                                                          Winston Garira
                                                          <<a href="mailto:Winston.Garira@univen.ac.za" rel="noreferrer noreferrer" target="_blank">Winston.Garira@univen.ac.za</a>><br>
                                                          <b>Subject:</b><span> </span>Re:
[Vp-integration-subgroup] Fwd: Shayn Peirce-Cottler via Frontiers:
                                                          Manuscript</font>
                                                          <div> </div>
                                                          </div>
                                                          <div>
                                                          <div style="font-family:Arial,Helvetica,sans-serif;font-size:10pt;border:1pt solid red;padding:2pt;background-color:yellow"><span style="color:red"><b>External Email:</b></span><span> Use caution in
                                                          opening links,
                                                          attachments,
                                                          and buying
                                                          gift cards.</span></div>
                                                          <br>
                                                          <div>
                                                          <div dir="ltr">Thanks
                                                          Alex, Thanks
                                                          John,
                                                          <div><br>
                                                          </div>
                                                          <div>Your
                                                          contribution
                                                          is appreciated
                                                          and since John
                                                          cleared us to
                                                          move
                                                          forward it
                                                          simplifies
                                                          things. I hope
                                                          he will change
                                                          his mind about
                                                          authorship
                                                          since he
                                                          contributed a
                                                          lot, yet I
                                                          will respect
                                                          his wishes -
                                                          perhaps after
                                                          seeing the
                                                          final version
                                                          he will change
                                                          his mind. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>If
                                                          Sheriff gives
                                                          me a green
                                                          light I can
                                                          incorporate
                                                          his
                                                          modifications
                                                          as well. I do
                                                          ask that if
                                                          any of the
                                                          listed authors
                                                          has any
                                                          serious
                                                          concerns and
                                                          plans to not
                                                          approve a
                                                          modified version
                                                          that addresses
                                                          the editors
                                                          requests alone
                                                          alongside
                                                          those I
                                                          mentioned
                                                          above, to step
                                                          up before the
                                                          work is done
                                                          so we can
                                                          resolve things
                                                          before energy
                                                          is spent. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>If there
                                                          will be no
                                                          blocks I plan
                                                          to start work
                                                          over the
                                                          weekend if I
                                                          see no
                                                          objections by
                                                          then.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>I
                                                          appreciate the
                                                          offer to help
                                                          with
                                                          bibliography,
                                                          from
                                                          experience I
                                                          know it is
                                                          perhaps the
                                                          most time
                                                          consuming.
                                                          However,
                                                          since we have
                                                          many links and
                                                          specialized
                                                          publications
                                                          in our list -
                                                          I am not sure
                                                          if any tool
                                                          can make it
                                                          easier - the
                                                          last time I
                                                          had to do a
                                                          lot of manual
                                                          work to fit a
                                                          specific
                                                          format and
                                                          find all
                                                          missing links
                                                          and also fix
                                                          some errors -
                                                          no tool would
                                                          have helped me
                                                          then. This
                                                          time I think
                                                          it will be a
                                                          bit easier.
                                                          Yet I ask for
                                                          no more
                                                          references to
                                                          be added - I
                                                          also want to
                                                          add more
                                                          references,
                                                          yet I am
                                                          stopping
                                                          myself. We can
                                                          always expand
                                                          the work in
                                                          another future
                                                          version if we
                                                          have new
                                                          findings. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>Again
                                                          note that I
                                                          will only try
                                                          to address the
                                                          requests of
                                                          the editor at
                                                          this point
                                                          without trying to
                                                          perfect
                                                          anything
                                                          beyond what I
                                                          wrote above
                                                          and I want to
                                                          keep things as
                                                          traceable as
                                                          possible. Once
                                                          I am done,we
                                                          will see if we
                                                          can approve
                                                          this
                                                          manuscript for
                                                          publication.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>Unless
                                                          any blockers
                                                          appear, if
                                                          anyone wants
                                                          to actively
                                                          participate in
                                                          the editing
                                                          over the
                                                          weekend,
                                                          please let me
                                                          know so we can
                                                          communicate
                                                          better.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>         
                                                           <span> </span>Jacob</div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          </div>
                                                          <br>
                                                          <div>
                                                          <div dir="ltr">On
                                                          Tue, Oct 19,
                                                          2021 at 2:02
                                                          AM Alexander
                                                          Kulesza <<a href="mailto:alexander.kulesza@novadiscovery.com" rel="noreferrer
                                                          noreferrer" target="_blank">alexander.kulesza@novadiscovery.com</a>>
                                                          wrote:<br>
                                                          </div>
                                                          <blockquote style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                                          <div dir="ltr">Dear
                                                          Jacob,
                                                          <div>thanks
                                                          for forwarding
                                                          and you
                                                          suggestions,
                                                          which seems
                                                          more than
                                                          reasonable. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>My
                                                          contributions
                                                          from May 19th,
                                                          May31st and
                                                          June 2nd are
                                                          in <a href="https://docs.google.com/document/d/1VvyP3YZQdQYjj8DFKOpQ4pn_0pdDGgiT/edit?usp=sharing&ouid=113860487708206439519&rtpof=true&sd=true" rel="noreferrer noreferrer" target="_blank">https://docs.google.com/document/d/1VvyP3YZQdQYjj8DFKOpQ4pn_0pdDGgiT/edit?usp=sharing&ouid=113860487708206439519&rtpof=true&sd=true</a> </div>
                                                          <div><br>
                                                          </div>
                                                          <div>The other
                                                          document <a href="https://docs.google.com/document/d/1esZvWWVBvpwvuFUi3C3161lthZkEBFyMRrwwozitBi4/edit?usp=sharing" rel="noreferrer noreferrer" target="_blank">https://docs.google.com/document/d/1esZvWWVBvpwvuFUi3C3161lthZkEBFyMRrwwozitBi4/edit?usp=sharing</a><span> </span>I
                                                          created
                                                          initially to
                                                          suggest my
                                                          edits without
                                                          editing the
                                                          core version
                                                          can be
                                                          disregarded as
                                                          I have
                                                          tranferred all
                                                          of them into
                                                          the main
                                                          document,
                                                          cited above. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>If we
                                                          were on Latex,
                                                          I could offer
                                                          to create the
                                                          bibliography
                                                          but
                                                          unfortunately
                                                          we lack a
                                                          bibliography
                                                          manager
                                                          integrated in
                                                          Word/GDoc. If
                                                          we were to
                                                          work with
                                                          Mendeley and
                                                          someone could
                                                          create a group
                                                          for this paper
                                                          that has a
                                                          shared library
                                                          I could offer
                                                          to transfer
                                                          citations from
                                                          the paper into
                                                          that database
                                                          too. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>Please
                                                          let me know.</div>
                                                          <div>A</div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          </div>
                                                          <br>
                                                          <div>
                                                          <div dir="ltr">On
                                                          Tue, 19 Oct
                                                          2021 at 05:51,
                                                          Jacob Barhak
                                                          <<a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a>>
                                                          wrote:<br>
                                                          </div>
                                                          <blockquote style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                                          <div dir="ltr">
                                                          <div>Greetings
                                                          white paper
                                                          contributors,</div>
                                                          <div><br>
                                                          </div>
                                                          <div>Below is
                                                          the response
                                                          from the
                                                          editor to my
                                                          request and my
                                                          thank you.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>The
                                                          editor grants
                                                          us the
                                                          extension by
                                                          rejecting the
                                                          paper and
                                                          allowing time
                                                          to come up
                                                          with a better
                                                          version. There
                                                          is no time
                                                          limit now, yet
                                                          I want to get
                                                          her a revised
                                                          version
                                                          within a
                                                          month. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>The
                                                          requests are
                                                          simple and
                                                          easy to
                                                          satisfy - and
                                                          I know there
                                                          are many of
                                                          you who want
                                                          more
                                                          revisions, yet
                                                          I suggest we
                                                          reduce them to
                                                          only what is
                                                          manageable and
                                                          necessary.
                                                          Otherwise we
                                                          will never get
                                                          this paper
                                                          published
                                                          despite its
                                                          importance. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>The most
                                                          time consuming
                                                          effort
                                                          would be
                                                          adhering to
                                                          the journal
                                                          format as
                                                          defined here:</div>
                                                          <div><a href="https://www.frontiersin.org/about/author-guidelines" rel="noreferrer noreferrer" target="_blank">https://www.frontiersin.org/about/author-guidelines</a><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div>I think
                                                          the most time
                                                          consuming task
                                                          would be
                                                          dealing with
                                                          the references
                                                          - otherwise
                                                          the format
                                                          guidelines seem
                                                          reasonable.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>We can
                                                          also add some
                                                          revisions we
                                                          started
                                                          working on.
                                                          However, I
                                                          will
                                                          personally
                                                          insist on :</div>
                                                          <div>1.
                                                          traceability -
                                                          currently
                                                          there is no
                                                          traceability
                                                          in the revised
                                                          version in the
                                                          summer</div>
                                                          <div>2. non
                                                          deletion - do
                                                          not delete any
                                                          content unless
                                                          you wrote it
                                                          originally or
                                                          unless you
                                                          announced it
                                                          beforehand to
                                                          the group and
                                                          got no
                                                          objections
                                                          within a few
                                                          days </div>
                                                          <div>3. Avoid
                                                          Adding more
                                                          material that
                                                          is not in the
                                                          existing
                                                          versions we
                                                          had -
                                                          especially
                                                          references -
                                                          we don't have
                                                          time for that
                                                          and that is
                                                          not what the
                                                          editor asked
                                                          us anyway. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>I will
                                                          also ask for
                                                          fast responses
                                                          from all
                                                          contributors. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>To be
                                                          practical, I
                                                          marked the
                                                          submitted
                                                          version and
                                                          opened the
                                                          document to
                                                          those who
                                                          requested
                                                          editing rights
                                                          in the past. 
                                                          If you want
                                                          editing
                                                          rights, let me
                                                          know -
                                                          however, the
                                                          edits should
                                                          be minimal and
                                                          focus on areas
                                                          you edited in
                                                          the past and
                                                          be aware that
                                                          if your edits
                                                          will not get
                                                          approved by
                                                          everyone, we
                                                          will revert to
                                                          the old
                                                          version we all
                                                          accepted. The
                                                          submitted
                                                          version
                                                          was marked so
                                                          we can always
                                                          get back to
                                                          it. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>If you
                                                          want editing
                                                          rights, let me
                                                          know and I
                                                          will respond
                                                          within a day -
                                                          I cannot
                                                          promise to be
                                                          fatter than
                                                          that these
                                                          days. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>Alex,
                                                          John, Sheriff,
                                                          you had other
                                                          versions you
                                                          created, I
                                                          want to merge
                                                          some of your
                                                          changes to the
                                                          manuscript in
                                                          this version -
                                                          here are my
                                                          suggestions:</div>
                                                          <div><br>
                                                          </div>
                                                          <div>-
                                                          Sheriff, I
                                                          will soften
                                                          the language
                                                          as you
                                                          requested -
                                                          this was your
                                                          main request
                                                          in the past,
                                                          yet I will go
                                                          over your list
                                                          of changes and
                                                          see what I
                                                          else can be
                                                          done without
                                                          reinventing
                                                          the paper</div>
                                                          <div>- John -
                                                          I will 1)
                                                          merge the
                                                          credibility
                                                          sections , 2)
                                                          delete the
                                                          history
                                                          related to the
                                                          working group
                                                          since it
                                                          matches with
                                                          what was
                                                          requested, and
                                                          3) move the
                                                          model
                                                          validation
                                                          barrier
                                                          section away
                                                          from the table
                                                          since we did
                                                          not suggest a
                                                          solution
                                                          there. 
                                                          Hopefully this
                                                          will make the
                                                          paper more
                                                          appealing to
                                                          you and you
                                                          will be
                                                          willing to add
                                                          your name to
                                                          the list  </div>
                                                          <div>- Alex,
                                                          your changes
                                                          were made
                                                          on May 16,
                                                          2021 and
                                                          shared in a
                                                          way I can see
                                                          the
                                                          differences
                                                          and trace them
                                                          back to you -
                                                          I will try to
                                                          add your
                                                          references and
                                                          see if I can
                                                          incorporate
                                                          your text
                                                          changes as
                                                          much as I
                                                          can. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>If the 3
                                                          of you are ok
                                                          with me
                                                          migrating your
                                                          changes, I can
                                                          start the work
                                                          to save time.
                                                          Yet I want
                                                          your ok
                                                          first. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>I know
                                                          Eric and Hana
                                                          were
                                                          working on
                                                          some sections
                                                          and feel
                                                          strongly about
                                                          those -
                                                          specifically
                                                          the stochastic
                                                          modeling part
                                                          - I am open to
                                                          your changes,
                                                          please suggest
                                                          what you feel
                                                          strongly
                                                          about..</div>
                                                          <div><br>
                                                          </div>
                                                          <div>I recall
                                                          Johnathan Karr
                                                          wanted to make
                                                          some changes,
                                                          please let me
                                                          know if there
                                                          is anything
                                                          you feel
                                                          strongly about
                                                          - he had a lot
                                                          of text in the
                                                          paper ..</div>
                                                          <div><br>
                                                          </div>
                                                          <div>If I
                                                          forgot anyone
                                                          who had
                                                          major requests,
                                                          please
                                                          remind me. .</div>
                                                          <div><br>
                                                          </div>
                                                          <div>I am
                                                          trying to
                                                          avoid a never
                                                          ending
                                                          revisioning
                                                          cycle. So I am
                                                          asking you to
                                                          trust me and
                                                          centralize the
                                                          work in hope I
                                                          get a better
                                                          version by the
                                                          end of the
                                                          week..</div>
                                                          <div><br>
                                                          </div>
                                                          <div>Hopefully
                                                          most of you
                                                          will be ok
                                                          with that.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>         
                                                               Jacob</div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          <div>
                                                          <div dir="ltr">----------
                                                          Forwarded
                                                          message
                                                          ---------<br>
                                                          From:<span> </span><strong dir="auto">Jacob
                                                          Barhak</strong><span> </span><span dir="auto"><<a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a>></span><br>
                                                          Date: Mon, Oct
                                                          18, 2021 at
                                                          9:34 PM<br>
                                                          Subject: Re:
                                                          Shayn
                                                          Peirce-Cottler
                                                          via Frontiers:
                                                          Manuscript<br>
                                                          To:
                                                          Peirce-Cottler,
                                                          Shayn (smp6p)
                                                          <<a href="mailto:smp6p@virginia.edu" rel="noreferrer noreferrer" target="_blank">smp6p@virginia.edu</a>><br>
                                                          Cc: Shayn
                                                          Peirce-Cottler
                                                          (Via
                                                          FrontiersIn)
                                                          <<a href="mailto:shayn@virginia.edu" rel="noreferrer noreferrer" target="_blank">shayn@virginia.edu</a>>,<a href="mailto:systemsbiology.editorial.office@frontiersin.org" rel="noreferrer
                                                          noreferrer" target="_blank">systemsbiology.editorial.office@frontiersin.org</a><span> </span><<a href="mailto:systemsbiology.editorial.office@frontiersin.org" rel="noreferrer
                                                          noreferrer" target="_blank">systemsbiology.editorial.office@frontiersin.org</a>>,
                                                          Vodovotz,
                                                          Yoram <<a href="mailto:vodovotzy@upmc.edu" rel="noreferrer noreferrer" target="_blank">vodovotzy@upmc.edu</a>><br>
                                                          </div>
                                                          <br>
                                                          <br>
                                                          <div dir="ltr">Thanks Shayn,
                                                          <div><br>
                                                          </div>
                                                          <div>You will
                                                          get a revised
                                                          manuscript
                                                          targeted at
                                                          your journal
                                                          and get back
                                                          to you with a
                                                          more polished
                                                          version and
                                                          satisfies your
                                                          requests. </div>
                                                          <div><br>
                                                          </div>
                                                          <div>It will
                                                          also allow us
                                                          to incorporate
                                                          newer versions
                                                          of the text
                                                          that answer
                                                          some of your
                                                          requests. We
                                                          really wish to
                                                          publish it
                                                          fast, yet we
                                                          need more
                                                          time for the
                                                          approval
                                                          process. So
                                                          your solution
                                                          seems correct
                                                          - I hope you
                                                          hear back from
                                                          us within a
                                                          month or so.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>Many thanks
                                                          for the rapid
                                                          responses.</div>
                                                          <div><br>
                                                          </div>
                                                          <div>         
                                                                 Jacob</div>
                                                          <div><br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          <div>--<br>
                                                          Jacob Barhak
                                                          Ph.D. <br>
                                                          Sole
                                                          Proprietor,
                                                          Software
                                                          Developer, and
                                                          Computational
                                                          Disease
                                                          Modeler<br>
                                                          <br>
                                                          Jacob Barhak
                                                          Analytics<br>
                                                          701 Brazos St<br>
                                                          Suite 548<br>
                                                          Austin TX,
                                                          78701<br>
                                                          <br>
                                                          Email:<span> </span><a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a></div>
                                                          <div><br>
                                                          <a href="https://sites.google.com/view/jacob-barhak/home" rel="noreferrer noreferrer" target="_blank">https://sites.google.com/view/jacob-barhak/home</a><br>
                                                          <br>
                                                          </div>
                                                          <div><br>
                                                          </div>
                                                          </div>
                                                          <br>
                                                          <div>
                                                          <div dir="ltr">On
                                                          Mon, Oct 18,
                                                          2021 at 7:43
                                                          PM
                                                          Peirce-Cottler,
                                                          Shayn (smp6p)
                                                          <<a href="mailto:smp6p@virginia.edu" rel="noreferrer noreferrer" target="_blank">smp6p@virginia.edu</a>>
                                                          wrote:<br>
                                                          </div>
                                                          <blockquote style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
                                                          <div lang="EN-US">
                                                          <div>
                                                          <p><span style="font-size:12pt">Hi
                                                          Jacob,<span> </span></span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <p><span style="font-size:12pt">Thank
                                                          you for your
                                                          detailed
                                                          reply. I agree
                                                          that the
                                                          issues can be
                                                          addressed as
                                                          you have
                                                          described
                                                          below, and
                                                          that you may
                                                          need more time
                                                          to do so.
                                                          Hence, I am
                                                          going to
                                                          officially
                                                          reject this
                                                          first
                                                          submission to
                                                          remove any
                                                          imposed
                                                          deadlines, and
                                                          I certainly
                                                          encourage you
                                                          to make the
                                                          updates listed
                                                          below, and
                                                          submit a new
                                                          manuscript at
                                                          your earliest
                                                          convenience.  </span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <p><span style="font-size:12pt">Please
                                                          let me know if
                                                          you have any
                                                          questions, and
                                                          thanks again
                                                          for
                                                          considering
                                                          this journal!
                                                          I think the
                                                          topic fits
                                                          very nicely
                                                          with the scope
                                                          of the
                                                          journal, and
                                                          it is
                                                          certainly an
                                                          important
                                                          topic to our
                                                          multi-scale
                                                          modeling
                                                          community!</span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <p><span style="font-size:12pt">-Shayn</span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <div>
                                                          <p><span>Shayn
Peirce-Cottler, Ph.D.</span></p>
                                                          <p><span>Professor
                                                          of Biomedical
                                                          Engineering</span></p>
                                                          <p><span>Harrison
                                                          Distinguished
                                                          Teaching
                                                          Professor</span></p>
                                                          <p><span>BME
                                                          Graduate
                                                          Program
                                                          Director</span></p>
                                                          <p><span>University
                                                          of Virginia</span></p>
                                                          </div>
                                                          <p><span>Charlottesville,
                                                          VA</span><span style="font-size:12pt"></span></p>
                                                          <p><span style="font-size:12pt"> </span></p>
                                                          <div style="border-style:solid none none;border-top-width:1pt;border-top-color:rgb(181,196,223);padding:3pt 0in 0in">
                                                          <p><b><span style="font-size:12pt">From:<span> </span></span></b><span style="font-size:12pt">Jacob Barhak <<a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a>><br>
                                                          <b>Date:<span> </span></b>Monday,
                                                          October 18,
                                                          2021 at 1:57
                                                          AM<br>
                                                          <b>To:<span> </span></b>Peirce-Cottler
                                                          Shayn <<a href="mailto:shayn@virginia.edu" rel="noreferrer noreferrer" target="_blank">shayn@virginia.edu</a>><br>
                                                          <b>Cc:<span> </span></b>"<a href="mailto:systemsbiology.editorial.office@frontiersin.org" rel="noreferrer
                                                          noreferrer" target="_blank">systemsbiology.editorial.office@frontiersin.org</a>"
                                                          <<a href="mailto:systemsbiology.editorial.office@frontiersin.org" rel="noreferrer noreferrer" target="_blank">systemsbiology.editorial.office@frontiersin.org</a>>,
                                                          "Vodovotz,
                                                          Yoram" <<a href="mailto:vodovotzy@upmc.edu" rel="noreferrer noreferrer" target="_blank">vodovotzy@upmc.edu</a>><br>
                                                          <b>Subject:<span> </span></b>Re:
                                                          Shayn
                                                          Peirce-Cottler
                                                          via Frontiers:
                                                          Manuscript</span></p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>Hi Shayn,</p>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>Thanks for
                                                          returning the
                                                          response
                                                          quickly. To
                                                          you comments. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>1. This is
                                                          the list of
                                                          authors that
                                                          agreed to
                                                          submit this
                                                          manuscript for
                                                          review - I
                                                          collected
                                                          their
                                                          approvals for
                                                          this version
                                                          personally. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <ol style="margin-top:0in" type="1" start="1">
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Jonathan Karr, Icahn Institute for
                                                          Data Science
                                                          and Genomic
                                                          Technology and
                                                          Department of
                                                          Genetics and
                                                          Genomic
                                                          Sciences,
                                                          Icahn School
                                                          of Medicine at
                                                          Mount Sinai
                                                          USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Rahuman Sheriff, The European
                                                          Bioinformatics
                                                          Institute
                                                          (EMBL-EBI), UK</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">James Osborne, School of
                                                          Mathematics
                                                          and
                                                          Statistics,
                                                          University of
                                                          Melbourne,
                                                          Australia</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Gilberto Gonzalez Parra,
                                                          Mathematics
                                                          Department,
                                                          New Mexico
                                                          Tech, USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Eric Forgoston, Department of
                                                          Applied
                                                          Mathematics
                                                          and
                                                          Statistics,
                                                          Montclair
                                                          State
                                                          University,
                                                          USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Ruth Bowness, Department of
                                                          Mathematical
                                                          Sciences,
                                                          University of
                                                          Bath, UK</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Yaling Liu, Department of
                                                          Mechanical
                                                          Engineering
                                                          and Mechanics
                                                          , Department
                                                          of
                                                          Bioengineering,
                                                          Lehigh
                                                          University,
                                                          USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Robin Thompson, Mathematics
                                                          Institute
                                                          & The
                                                          Zeeman
                                                          Institute for
                                                          Systems
                                                          Biology and
                                                          Infectious
                                                          Disease
                                                          Epidemiology
                                                          Research,
                                                          University of
                                                          Warwick, UK</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Winston Garira - Department Of
                                                          Mathematics
                                                          And Applied
                                                          Mathematics ,
                                                          Modelling
                                                          Health and
                                                          Environmental
                                                          Linkages
                                                          Research
                                                          Group.
                                                          University of
                                                          Venda, South
                                                          Africa</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Jacob Barhak - Barhak, Jacob, USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">John Rice - Independent Retired
                                                          Working Group
                                                          Volunteer, USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Marcella Torres, School of Arts and
                                                          Sciences,
                                                          University of
                                                          Richmond, USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Hana M. Dobrovolny , Department of
                                                          Physics &
                                                          Astronomy,
                                                          Texas
                                                          Christian
                                                          University,
                                                          Fort Worth,
                                                          USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">Tingting Tang, Department of
                                                          Mathematics
                                                          and Statistics
                                                          in San Diego
                                                          State
                                                          University
                                                          (SDSU) and
                                                          SDSU Imperial
                                                          Valley, USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">William Waites, Centre for
                                                          Mathematical
                                                          Modelling of
                                                          Infectious
                                                          Diseases,
                                                          London School
                                                          of Hygiene and
                                                          Tropical
                                                          Medicine, UK</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">James Glazier, Biocomplexity
                                                          Institute,
                                                          Indiana
                                                          University,
                                                          Bloomington,
                                                          USA</span></li>
                                                          <li style="margin-top:0in;margin-bottom:0in;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal"><span style="font-family:Arial,sans-serif">James R. Faeder, Department of
                                                          Computational
                                                          and Systems
                                                          Biology,
                                                          University of
                                                          Pittsburgh,
                                                          Pittsburgh,
                                                          USA</span></li>
                                                          </ol>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>If there is
                                                          a mismatch of
                                                          authors in the
                                                          submission, it
                                                          can be easily
                                                          corrected - we
                                                          kept the paper
                                                          traceable when
                                                          we constructed
                                                          it so we can
                                                          point to exact
                                                          texts
                                                          contributed by
                                                          each
                                                          contributor
                                                          through their
                                                          google account
                                                          and versions
                                                          kept in google
                                                          docs with few
                                                          exceptions
                                                          where I
                                                          personally
                                                          added text
                                                          their wrote
                                                          and have email
                                                          conversations
                                                          supporting
                                                          that .  I
                                                          personally
                                                          collected all
                                                          those
                                                          contributions
                                                          in google docs
                                                          when I
                                                          assembled the
                                                          version you
                                                          see and made
                                                          sure it is
                                                          agreed upon by
                                                          the
                                                          contributors.
                                                          It is
                                                          important to
                                                          note that
                                                          There was one
                                                          contributor
                                                          that asked for
                                                          more revisions
                                                          and did not
                                                          approve this
                                                          manuscript,
                                                          yet allowed
                                                          submitting the
                                                          text without
                                                          association to
                                                          it to avoid
                                                          delays. The
                                                          entire
                                                          conversation
                                                          was documented
                                                          publicly in
                                                          our mailing
                                                          list and we
                                                          got consent
                                                          from this
                                                          contributor to
                                                          continue and
                                                          use the text -
                                                          You can find
                                                          the
                                                          conversation 
                                                          here:<span> </span><a href="https://lists.simtk.org/pipermail/vp-reproduce-subgroup/2021-March/000019.html" rel="noreferrer noreferrer" target="_blank">https://lists.simtk.org/pipermail/vp-reproduce-subgroup/2021-March/000019.html</a> <span> </span>- 
                                                          so there are
                                                          no copyright
                                                          issues and the
                                                          name of the
                                                          author is not
                                                          included in
                                                          the list above
                                                          at their
                                                          request. Those
                                                          included in
                                                          the list have
                                                          contributed
                                                          and approved.
                                                          If needed, we
                                                          will correct
                                                          the list in
                                                          the journal to
                                                          match this
                                                          list. Please
                                                          note that we
                                                          kept the
                                                          entire process
                                                          as transparent
                                                          as possible so
                                                          there will be
                                                          no issues. If
                                                          there are any
                                                          concerns of
                                                          authorship, I
                                                          will be happy
                                                          to dig into
                                                          the history
                                                          and pull out
                                                          details. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>2. The
                                                          reason the
                                                          manuscript was
                                                          submitted in
                                                          this form is
                                                          to get
                                                          confirmation
                                                          on initial fit
                                                          and to get
                                                          some initial
                                                          feedback. We
                                                          were
                                                          interested in
                                                          fast review to
                                                          get the
                                                          information
                                                          quickly out -
                                                          Also note that
                                                          we did not
                                                          intend this to
                                                          be a final
                                                          version - we
                                                          already have
                                                          some
                                                          modifications
                                                          in the work
                                                          that we would
                                                          like to
                                                          introduce
                                                          where more
                                                          people
                                                          contributed ,
                                                          yet we have
                                                          not reached
                                                          agreement on
                                                          those so we
                                                          cannot
                                                          formally
                                                          publish them -
                                                          however, we
                                                          did reach
                                                          agreement on
                                                          submitting
                                                          this version
                                                          for review so
                                                          the editor can
                                                          focus us on
                                                          what is
                                                          important to
                                                          change to get
                                                          published with
                                                          a 3rd Party -
                                                          enough of us
                                                          agreed in a
                                                          vote that your
                                                          Journal seems
                                                          is a suitable
                                                          3rd party and
                                                          hence the
                                                          submission. We
                                                          will be happy
                                                          to spend the
                                                          time to
                                                          convert the
                                                          manuscript to
                                                          the desired
                                                          format if you
                                                          find the
                                                          content
                                                          suitable for
                                                          the journal.
                                                          So far your
                                                          requests are
                                                          reasonable and
                                                          I will convey
                                                          them to the
                                                          group through
                                                          our mailing
                                                          list. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>3. Please
                                                          note that
                                                          after the list
                                                          of authors
                                                          there is a
                                                          disclaimer : "<span style="font-family:Arial,sans-serif">The opinion of the contributors do
                                                          not reflect
                                                          the opinions
                                                          of the entire
                                                          working
                                                          group". I</span>nitially
                                                          this paper
                                                          started as an
                                                          activity
                                                          requested by
                                                          the working
                                                          group leads.
                                                          However, by no
                                                          means it
                                                          represents all
                                                          opinions. The
                                                          introduction
                                                          in this
                                                          version of the
                                                          paper captures
                                                          some of this
                                                          history of how
                                                          the manuscript
                                                          was created
                                                          and modified.
                                                          However, we
                                                          have other
                                                          versions of
                                                          the manuscript
                                                          in work where
                                                          this history
                                                          is deleted -
                                                          If you prefer,
                                                          we can easily
                                                          create a
                                                          version that
                                                          detaches from
                                                          the working
                                                          group to
                                                          eliminate all
                                                          concerns -
                                                          this is a
                                                          relatively
                                                          easy fix.
                                                          However,
                                                          whatever fix
                                                          we do, we will
                                                          have to
                                                          approve with
                                                          all
                                                          contributors. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>4  The
                                                          revisions can
                                                          be done in
                                                          reasonable
                                                          time. However,
                                                          the process of
                                                          collecting
                                                          approval for
                                                          all
                                                          contributors
                                                          to legally
                                                          approve the
                                                          revised
                                                          manuscript
                                                          will take more
                                                          than 14 days.
                                                          All
                                                          contributors
                                                          must approve a
                                                          manuscript for
                                                          publication.
                                                          With this
                                                          number of
                                                          authors we
                                                          will probably
                                                          not make it in
                                                          the time you
                                                          mentioned -
                                                          only the
                                                          approval
                                                          process for
                                                          collecting all
                                                          approvals took
                                                          alone about 3
                                                          weeks to
                                                          approve this
                                                          version you
                                                          see. 
                                                          Hopefully you
                                                          will
                                                          understand
                                                          this and
                                                          extend this
                                                          time period
                                                          beyond 14
                                                          days. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>In
                                                          summary: </p>
                                                          </div>
                                                          <div>
                                                          <p>Making the
                                                          fixes you
                                                          asked for
                                                          towards
                                                          publication is
                                                          easy - yet
                                                          getting the
                                                          approval from
                                                          so many people
                                                          may take us
                                                          more time than
                                                          what you
                                                          provide. If it
                                                          is possible to
                                                          get an
                                                          extension, it
                                                          will be
                                                          appreciated. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>I will add
                                                          this
                                                          conversation
                                                          to our mailing
                                                          list so we can
                                                          start the
                                                          process of
                                                          revising the
                                                          manuscript. 
                                                          However, if
                                                          after this
                                                          email you have
                                                          more issues
                                                          with this
                                                          paper, Please
                                                          advise on the
                                                          best course of
                                                          action you see
                                                          fit so we can
                                                          adjust
                                                          accordingly. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>Hopefully
                                                          we can address
                                                          your concerns
                                                          in time to
                                                          publish the
                                                          manuscript in
                                                          a timely
                                                          manner. </p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p>           
                                                               Jacob</p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          <div>
                                                          <p style="margin-bottom:12pt">--<br>
                                                          Jacob Barhak
                                                          Ph.D. <br>
                                                          Sole
                                                          Proprietor,
                                                          Software
                                                          Developer, and
                                                          Computational
                                                          Disease
                                                          Modeler<br>
                                                          <br>
                                                          Jacob Barhak
                                                          Analytics<br>
                                                          701 Brazos St<br>
                                                          Suite 548<br>
                                                          Austin TX,
                                                          78701<br>
                                                          <br>
                                                          Email:<span> </span><a href="mailto:jacob.barhak@gmail.com" rel="noreferrer noreferrer" target="_blank">jacob.barhak@gmail.com</a><br>
                                                          <br>
                                                          <a href="https://sites.google.com/view/jacob-barhak/home" rel="noreferrer noreferrer" target="_blank">https://sites.google.com/view/jacob-barhak/home</a></p>
                                                          </div>
                                                          <div>
                                                          <p> </p>
                                                          </div>
                                                          </div>
                                                          <p> </p>
                                                          <div>
                                                          <div>
                                                          <p>On Sun, Oct
                                                          17, 2021 at
                                                          9:56 AM Shayn
                                                          Peirce-Cottler
                                                          (Via
                                                          FrontiersIn)
                                                          <<a href="mailto:noreply@frontiersin.org" rel="noreferrer noreferrer" target="_blank">noreply@frontiersin.org</a>>
                                                          wrote:</p>
                                                          </div>
                                                          <blockquote style="border-style:none none none solid;border-left-width:1pt;border-left-color:rgb(204,204,204);padding:0in 0in 0in 6pt;margin-left:4.8pt;margin-right:0in">
                                                          <div>
                                                          <p>Dear Jacob,<span> </span><br>
                                                          <br>
                                                          Thank you for
                                                          your
                                                          manuscript
                                                          submission. I
                                                          cannot send it
                                                          out for review
                                                          in its current
                                                          form because I
                                                          have a few
                                                          concerns, but
                                                          if you can
                                                          address the
                                                          following
                                                          issues, I will
                                                          certainly
                                                          reconsider a
                                                          revised
                                                          manuscript if
                                                          the following
                                                          are adequately
                                                          addressed:<br>
                                                          <br>
                                                          1. The author
                                                          list that is
                                                          on the first
                                                          page differs
                                                          from the
                                                          author list
                                                          that was
                                                          provided at
                                                          the time of
                                                          submission.<span> </span><br>
                                                          <br>
                                                          2. The
                                                          manuscript
                                                          needs to be
                                                          submitted
                                                          using the
                                                          official
                                                          Frontiers
                                                          template.<br>
                                                          <br>
                                                          3. The
                                                          manuscript
                                                          states that it
                                                          represents the
                                                          views of a
                                                          number of
                                                          special
                                                          interest and
                                                          working
                                                          groups, and
                                                          the authors
                                                          should provide
                                                          assurances
                                                          that they have
                                                          the authority
                                                          and approval
                                                          to speak on
                                                          behalf of the
                                                          working groups
                                                          that are
                                                          listed.<br>
                                                          <br>
                                                          4. There are
                                                          places
                                                          throughout the
                                                          manuscript,
                                                          and most
                                                          frequently in
                                                          the second
                                                          half, where
                                                          information is
                                                          provided as
                                                          bulleted
                                                          talking points
                                                          without
                                                          context. Those
                                                          sections
                                                          should be
                                                          revised into
                                                          paragraphs of
                                                          text or
                                                          summarized in
                                                          a table (or
                                                          figure).<br>
                                                          <br>
                                                          If you wish to
                                                          submit a
                                                          revised
                                                          manuscript,
                                                          the journal
                                                          provides a
                                                          14-day time
                                                          window for you
                                                          to do so.
                                                          Please let me
                                                          know if you
                                                          have any
                                                          questions.<span> </span><br>
                                                          <br>
                                                          Thank you,<br>
                                                          Shayn<br>
                                                          <br>
                                                          <br>
---------------------------------<br>
                                                          <br>
                                                          Manuscript
                                                          title: Model
                                                          Integration in
                                                          Computational
                                                          Biology: The
                                                          Role of
                                                          Reproducibility,
                                                          Credibility
                                                          and Utility<br>
                                                          Manuscript ID:
                                                          793932<br>
                                                          Authors:
                                                          Marcella
                                                          Torres, Jacob
                                                          Barhak, Ruth
                                                          Bowness, Hana
                                                          Maria
                                                          Dobrovolny,
                                                          James Faeder,
                                                          Eric
                                                          Forgoston,
                                                          Winston
                                                          Garira, Yaling
                                                          Liu, James
                                                          Osborne,
                                                          Gilberto
                                                          Gonzalez
                                                          Parra, John
                                                          Rice, Rahuman
                                                          Sheriff,
                                                          Tingting Tang,
                                                          Robin
                                                          Thompson,
                                                          William Waites<span> </span><br>
                                                          Date
                                                          submitted: 12
                                                          Oct 2021<span> </span><br>
                                                          Edited by:
                                                          Shayn
                                                          Peirce-Cottler<br>
                                                          <br>
                                                          <br>
                                                          Research
                                                          Topic:
                                                          Insights in
                                                          Systems
                                                          Biology:
                                                          Multiscale
                                                          Mechanistic
                                                          Modeling 2021<br>
                                                          Review forum
                                                          direct access
                                                          link:<span> </span><a href="http://links.email.frontiersin.org/ls/click?upn=AAaFa03elZRFPXQ6ShiKwHJ7IVBhf38O-2BEQWinpomFtULO0Q-2BM19TTRdh7emL5NqrxgHYRG7-2FEazDF-2FJfPddug-3D-3Dkdpa_6U3AlnyvMxxXqGK2YZZvqQDAig2dZVa43D-2BB81ORWCaNWR45ZJ2fDhpaKsTZzRsuCL-2BNJFR2MRucSNQVfNAGmtHQx1gGGhLotkRxEWQuZDre0jQti6pSzF-2Bm1akZB-2FZLJbzjJjEqrnF6c-2BY79oozDKNeyZDGEV7E7qizJmMtyvWGMFEr4JK1z0YPzIbG66EloII5-2FSNkwoWo-2BqqYbe1fAtco01e7-2FlRQb33KpEVuKlNimzGXjW3kPgAYf1R6wsCnLhi7Aow94qLbu0WkYgbBRg-3D-3D" rel="noreferrer noreferrer" target="_blank">https://review.frontiersin.org/review/793932/0/0</a><span style="border:1pt solid windowtext;padding:0in"><img id="gmail-m_-283976446094332176gmail-m_-6812091254919142191gmail-m_-2697268861042949202gmail-m_-1689782665546364892gmail-m_454394027104465375gmail-m_1100449795159862914gmail-m_-3690383742767868331gmail-m_208464925022974690gmail-m_-6684231236743761144gmail-m_5330779350599904174m_6811753030514762076gmail-m_-4652177745642668797m_-8816081919050643472x_gmail-m_1182346046610349769gmail-m_-3593486653867666975m_3106702485682359377m_-7813573733557270536m_-7842715099430849307gmail-m_622710468663863154_x0000_i1025" alt="Image
                                                          removed by
                                                          sender." style="width: 0.0104in; height: 0.0104in;" width="1" height="1" border="0"></span></p>
                                                          </div>
                                                          </blockquote>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </blockquote>
                                                          </div>
                                                          </div>
                                                          </div>
                                                          </div>
_______________________________________________<br>
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                                                          </blockquote>
                                                          </div>
                                                          <br clear="all">
                                                          <div><br>
                                                          </div>
                                                          --<span> </span><br>
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                                                          message is
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</pre>
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    <pre cols="72">-- 
James A. Glazier, PhD
Professor of Intelligent Systems Engineering, Adjunct Professor of Physics
Director, Biocomplexity Institute
Indiana University, Bloomington
(812) 391-2159 (cell)</pre>
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