<div dir="ltr"><div>Hello all,</div><div><br></div><div>We received some guidance on how to proceed. However, we might have some changes depending on the situation. </div><div><br></div><div><p class="MsoNormal"><span style="font-family:Arial,sans-serif;color:black">Charge to subgroups:<u></u><u></u></span></p><p class="MsoNormal"><span style="font-family:Arial,sans-serif;color:black">Deliverable: White paper on the subgroup focus areas.<u></u><u></u></span></p><p class="MsoNormal"><span style="font-family:Arial,sans-serif;color:black">Due date: February 26, 2021<u></u><u></u></span></p><p class="MsoNormal"><span style="font-family:Arial,sans-serif;color:black"><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-family:Arial,sans-serif;color:black">Steps to be taken:<u></u><u></u></span></p><ol start="1" type="1" style="margin-bottom:0in"><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">Subgroup lead(s) <b>write one or two paragraphs on the topic of the subgroup</b> and the main problems to be focused on. Due to working group leads: <b>January 17</b><u></u><u></u></span></li><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">Email to all subgroup members with this description and call for an initial meeting (if not happened yet) on or before <b>January 26</b>. Bruce can help with address lists and scheduling.<u></u><u></u></span></li><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">At the initial meeting, discussion of the main topics of a white paper that surveys the subgroup topic and lists major problems and potential solutions. Refine paragraph describing subgroup focus. Sketch out an initial Google doc with these problems. Post it on working group website.<u></u><u></u></span></li><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">Subsequently, subgroup leads develop a document based on the meeting with sections for main topics and find leads for each of the sections. Completed by <b>January 29</b>.<u></u><u></u></span></li><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">Leads for main topics draw on other subgroup members to complete an initial draft by <b>February 12</b>.<u></u><u></u></span></li><li class="MsoNormal" style="margin-left:15px;color:black"><span style="font-family:Arial,sans-serif">Entire subgroup edits, refines, expands document, including references etc. Final document delivered to working group leads by <b>February 26</b>.</span></li></ol></div><div><br></div><div><br></div><div>Regarding step 1 Jacobe wrote a draft paper and I added that we might start with Covid due to the importance of this topic. However, it is open as it can be seen below.</div><div><br></div><div><br></div><div><span id="gmail-docs-internal-guid-f08bc4a8-7fff-0ece-c7db-cb5d801e92ff"><p dir="ltr" style="line-height:1.38;text-align:center;margin-top:0pt;margin-bottom:0pt"><span style="font-size:12pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">COMORBIDITIES SUBGROUP</span></p><p dir="ltr" style="line-height:1.38;text-align:center;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">MSM WORKING GROUP ON MULTISCALE MODELING OF VIRAL PANDEMICS</span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Any disease has multiple effects on the human body, partially since it can affect multiple organs or systems. The definition of complications of a disease is many times determined by medical experts that employ language or codes such as International Statistical Classification of Diseases and Related Health Problems (ICD). This is a human decision process that involves many factors a trained medical professional takes into account, including education, and experience. Computational models are different from human decision and therefore there is a need to address how those address comorbidities. </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">This subgroup deals with comorbidities such as:</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">- Diabetes</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">- Age</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">- Obesity</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">- Immune suppression</span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Issues to explore:</span></p><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">What comorbidities exist in viral infections and how can we model those?</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">How to include human interpretation of modeling?</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Multiscale computational models can model quantities rather than states. How to transform a quantity to a definition of a comorbidity?</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">How to model interaction between comorbidities?</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">What are examples of existing models known and how do those define comorbidities?</span></p></li></ul><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Note:</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Due to the current COVID-19 pandemic these previous points can be addressed specifically for COVID.</span></p><br></span></div><div>If you have some suggestions you can use the simtk list. </div><div><br></div><div>Best,</div><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr">***************************************************************************</div><div dir="ltr">Gilberto C. Gonzalez-Parra, <span style="color:rgb(0,0,0);font-family:"Helvetica Neue",Helvetica,Arial,"Lucida Grande",sans-serif,serif,EmojiFont;font-size:13px">Ph.D in Applied Mathematics.</span></div><div dir="ltr"><font color="#000000" face="Helvetica Neue, Helvetica, Arial, Lucida Grande, sans-serif, serif, EmojiFont"><span style="font-size:13px">Faculty of the </span></font>Mathematics Department<div><div>New Mexico Tech, NM, USA.</div></div><div>****************************************************************************</div></div></div></div></div></div></div></div></div></div></div><div id="DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2"><br>
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