[Population Modeling] Re: PopModWkGrpIMAG-news Digest, Vol 3, Issue 2

Bradley Davidson Bradley.Davidson at du.edu
Mon Jan 5 05:45:32 PST 2015 

My contribution to the paper pasted below. Thank you for allowing me to be
a part of this group; I look forward to participating in the discussions
in the new year!
Brad

Bradley Davidson, Ph.D.
Assistant Professor
Mechanical and Materials Engineering
University of Denver
(303) 871-2133




Our goal at the University of Denver is to simulate population-based
randomized controlled trials (RCTs) with realistic treatment effects using
efficient probabilistic techniques. This represents a fundamental shift in
how
to use musculoskeletal simulation. We recently created a probabilistic
³wrapper²
for OpenSim (https://simtk.org/home/prob_tool) to perform musculoskeletal
simulations that Account
for uncertainty and variability from multiple sources. The probabilistic
interface
uses traditional Monte Carlo simulations (Reinbolt et al. 2007, Valente et
al. 2013)
and more efficient and innovative methods such Advanced Mean Value Easley
et al. 2007) to simulate realistic
affects of population variability. We recently demonstrated the ability of
the
interface to analyze the effects of experimental error (marker placement,
movement artifacts) and parameter uncertainty (e.g. body segment
parameters,
muscle parameters) within patient-specific simulations (Myers et al. in
press).



Myers, C. A., Laz, P.J., Shelburne, K. B., Davidson, B. S. A
probabilistic approach to quantify the impact of uncertainty propagation in
musculoskeletal simulations. Annals of Biomedical Engineering doi:
10.1007/s10439-014-1181-7


Reinbolt, J. A., Haftka, R. T., Chmielewski, T. L. &
Fregly, B. J. Are patient-specific joint and inertial parameters necessary
for
accurate inverse dynamics analyses of gait? IEEE Transactions on Biomedical
Engineeringngineering 54, 782­93 (2007).

Valente, G., Taddei, F. & Jonkers, I. Influence of weak
hip abductor muscles on joint contact forces during normal walking:
probabilistic modeling analysis. Journal of Biomechanics 1­8 (2013).


	





On 1/4/15, 3:06 AM, "popmodwkgrpimag-news-request at simtk.org"
<popmodwkgrpimag-news-request at simtk.org> wrote:

>Send PopModWkGrpIMAG-news mailing list submissions to
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>When replying, please edit your Subject line so it is more specific
>than "Re: Contents of PopModWkGrpIMAG-news digest..."
>
>
>Today's Topics:
>
>   1. RE: Soliciting contributions for a population	modeling paper
>      (Jacob Barhak)
>
>
>----------------------------------------------------------------------
>
>Message: 1
>Date: Sat, 3 Jan 2015 16:46:44 -0600
>From: Jacob Barhak <jacob.barhak at gmail.com>
>Subject: RE: [Population Modeling] Soliciting contributions for a
>	population	modeling paper
>To: Olaf Dammann <Olaf.Dammann at tufts.edu>
>Cc: popmodwkgrpimag-news at simtk.org
>Message-ID:
>	<CAM_y+3SDJMvjKdBDN8He+eDaeW-zFZHC8oNgafDOsXPMTa_C=A at mail.gmail.com>
>Content-Type: text/plain; charset="utf-8"
>
>Hi Olaf,
>
>You attached your blurb as a document rather than as text,  so it does not
>show in the archives well. It is a binary file not easily accesible
>through
>a mobile device.
>
>In the future, please avoid sending attachments to the list. Better send
>links if necessary.
>
>I decided to resubmit the text again,  so people will have access to the
>text even if they don't receive it as an email.
>
>I hope people can read this now.
>
>          Jacob
>
>######### Olaf's text ########
>
>The Tufts Population Modeling group is interested in occurrence patterns
>of
>developmental disabilities and their risk factors [1]. We take a bottom-up
>approach in transition-likelihood simulations of birth cohorts. The idea
>is
>to simulate disease occurrence in virtual populations that can be compared
>to published data. We have come to call this approach ³systems
>epidemiology²[2], which involves observation in populations and population
>modeling, in order to complement systems biology, which involves
>biological
>experimentation and computational modeling of individual entities. Our
>current project is centered around the question: What respective roles do
>oxygen exposure and neonatal infection play in the etiology of retinopathy
>of prematurity [3]?
>
>
>
>1. Dammann, O. and P. Follett, Toward multi-scale computational modeling
>in
>developmental disability research. Neuropediatrics, 2011. 42(3): p. 90-6.
>
>2. Dammann, O., et al., Systems Epidemiology: What's in a Name? Online
>Journal of Public Health Informatics, 2014. 6(3).
>
>3. Hellstrom, A., L.E. Smith, and O. Dammann, Retinopathy of
>prematurity. Lancet, 2013. 382(9902): p. 1445-57.
>
>
>
>Olaf Dammann (Tufts Public Health)
>
>Benjamin Hescott (Tufts Computer Science)
>
>On Dec 9, 2014 10:51 AM, "Dammann, Olaf" <Olaf.Dammann at tufts.edu> wrote:
>
>>  Dear Jacob & All,
>>
>> Grand idea! See attached for our 2 cents.
>>
>> Best wishes,
>>
>> Olaf & Ben
>>
>>
>>
>> *From:* Jacob Barhak [mailto:jacob.barhak at gmail.com]
>> *Sent:* Monday, December 08, 2014 9:28 PM
>> *To:* popmodwkgrpimag-news at simtk.org
>> *Subject:* [Population Modeling] Soliciting contributions for a
>> population modeling paper
>>
>>
>>
>> Greetings all population modeling members,
>>
>> Sergey and I discussed writing a population modeling paper. In the IMAG
>> meeting we tried to define population modeling by a set of terms you can
>> find in the IMAG site,  yet definition by example may be better.
>>
>> Therefore we are soliciting contributions from all list members. The
>>idea
>> would be to define this group by collecting examples of work from each
>> member.
>>
>> To this end,  I would ask for everyone receiving this post to reply to
>>it
>> with one paragraph about what they do within population modeling. And
>> please add at least one reference to own work.
>>
>> I volunteer to assemble the paragraphs and references into a paper and
>> submit it to one of the SCS conferences using the names of all
>>contributors
>> who post to the list. You are  welcome to invite coleagues to join this
>> thread or suggest another target venue to the paper.
>>
>> I look forward to read your introductions to your own work.
>>
>>          Jacob
>>
>> --
>> Jacob Barhak Ph.D.
>> http://sites.google.com/site/jacobbarhak/
>>
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>End of PopModWkGrpIMAG-news Digest, Vol 3, Issue 2
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